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Men may experience more pronounced abdominal and visceral fat reduction, while women may notice improvements in both truncal and lower body fat depending on receptor distribution and individual physiology

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Tesofensine, a Novel Triple Monoamine Reuptake Inhibitor, Induces Appetite Suppression by Indirect Stimulation of 1 Adrenoceptor and Dopamine D1 Receptor Pathways in the Diet-Induced Obese Rat

If simple measures do not provide relief within two to three weeks, further medical review is appropriate to exclude other causes and consider alternative supplementation routes