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Meanwhile, PLIN1 predominates and envelops large LDs in macrophages, resulting in the downregulation of lipid efflux proteins ATP-binding cassette transporter A Member 1 (ABCA1) and ATP Binding Cassette Subfamily G Member 1 (ABCG1), a critical process for constraining the development of macrophage inflammatory phenotype and providing protection against atherosclerotic lesions [35]
