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This Perspective discusses the emerging cellular roles of lysine lactylation, with a focus on the lactyl-CoA-independent pathway, and highlights the potential strategies of targeting lactylation for the treatment of associated human diseases.

A tripeptide is a peptide consisting of three amino acids (cysteine, glycine, and glutamic acid)

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Mice treated with rutin showed reduced erythema, scaling, and epidermal thickening compared to mice without treatment