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No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate

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Mechanism of Action AOD9604 exerts its metabolic effects through mechanisms that remain incompletely characterized but appear to involve direct stimulation of lipolysis and inhibition of lipogenesis in adipose tissue through pathways independent of the classical growth hormone receptor