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Funct Plant Biol 31:359368 Hossain MA, Li ZG, Hoque TS, Burritt DJ, Fujita M, Munne-Bosch S (2017) Heat or cold priming-induced cross-tolerance to abiotic stresses in plants: key regulators and possible mechanisms

This is curious because of the general assumption that nuclear IGF-1R cannot be accessed by antibodies - crossing the membrane is challenging and import to the nucleus of an antibody bound to IGF-1R is unlikely because of the size of the complex

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While they are associated with increased WBCs, there is little evidence that attempting to modulate them will affect your immune system in any significant or beneficial way