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It is not common, but it is the primary reason we adjust or discontinue GHK-Cu protocols when side effects arise

In a Wistar-rat Achilles-detachment model, intraperitoneal BPC 157 at 10 g/kg, 10 ng/kg, or 10 pg/kg was administered daily from 30 minutes post-surgery
In recent years, it has been extensively studied for its potent therapeutic effects on diseases and low cytotoxicity

And, in the case of my pond, it is why ice forms on the surface and freezes downward versus freezing from the bottom up