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Permeation Data: In-vitro diffusion studies demonstrated a 3.5-fold increase in dermal flux compared to the unencapsulated control

This Cu 2+ -cuprizone complex could not cross the intestinal epithelial barrier in an ex vivo experiment on mice intestines, which was thought to cause systemic copper deficiency [92]

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in its active form (thiamine diphosphate), it is an essential cofactor for enzymes in glucose and amino acid catabolism, helping convert nutrients into ATP and supporting normal neuronal function