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Passos J, Soares MP, Salgado D, et al

However, integrative oncology is increasingly investigating NCs as synergistic partners with standard therapies to improve efficacy and reduce toxicity ( Overall, NCs such as alkaloids, flavonoids, polyphenols, terpenoids, and isothiocyanates have shown potent chemopreventive and chemosensitizing effects in OC through a variety of mechanisms, affecting important pathways like PI3K/Akt/mTOR, NF-B, Wnt/-catenin, and MAPK (Table 1)

This presentation strongly suggests left-sided heart failure secondary to chronic rheumatic heart disease, which characteristically causes mitral stenosis due to fused commissures

We show that IL-1 produced by DM heart macrophages targets cardiomyocytes to induce cardiac arrhythmias