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Adicionalmente, la sibutramina produce un aumento de la frecuencia cardiaca y la presin sangunea, que pueden ser clnicamente significativas en algunos pacientes, habindose registrado casos de arritmias, cardiopatas isqumicas y accidentes vasculares graves con su consumo

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Stabilization of multidomain proteins To further elucidate osmolyte mechanisms of action, we took advantage of the peptide-level resolution of LiPMS to ask whether osmolytes can stabilize single domains of multidomain proteins