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Each of the four Klow components has been studied in different preclinical models, and each is associated in published literature with a distinct mechanistic pathway rather than a shared effect

They found that the number of cross-linked collagen molecules declined with an increasing dose of PXS-S2A.The compound also reduced tissue stiffness, even at low concentrations, suggesting that blocking LOXL-2/LOXL-3 could be an effective way to reduce tissue stiffness

A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cells

However, the mechanistic rationale for combining these agents is sound and warrants further investigation