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Other metal chelating proteins also include transferrin and serum albumin, which play a key role in indirect antioxidant defence by sequestering free metal ions such as Fe 2 and Cu 2 , preventing their participation in redox reactions that generate highly reactive species such as hydroxyl radical ( OH) [22]
Metformin has been shown (134) to induce iron apoptosis and increase ROS levels in hepatocellular carcinoma cells via ATF4/STAT3, thereby decreasing hepatocellular carcinoma cell resistance to sorafenib

Its like a slow-release energy bar for your cells
Myth: All collagen and glutathione supplements work the same
