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Description
Metformin can interfere with the absorption of vitamin B12 in the small intestine, leading to lower B12 levels over time
It's frequently referenced alongside MOTS-c and NAD+ in research contexts, given the complementary nature of their respective pathway interactions - particularly how NNMT inhibition influences NAD+ availability in metabolic signalling studies
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One of its principal targets is PARP, a nuclear enzyme involved in DNA repair and cellular stress responses
