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H 2 O 2 can also regulate autophagy by modulating the activity of mTORC1

The closest FDA-approved IGF-1 product is mecasermin (Increlex) , native recombinant human IGF-1, approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or GH gene deletion with neutralizing antibodies

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In prostate cancer, a study demonstrated that APS-mediated upregulation of miR-133a in DU145 cells effectively inhibited proliferation, invasion, and migration by targeting oncogenic pathways (146)