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The mice were once intravenously injected with cisplatin in a single half-lethal dose of 15 mg/kg (this dose caused a death of 50% of the animals)

By employing a conditional gene expression strategy on an ApoE knockout background to eliminate interference from endogenous central ApoE, the study demonstrated that peripheral expression of ApoE4 alone is sufficient to induce memory impairment, BBB leakage, and perivascular gliosis, with a severity comparable to that observed in systemic ApoE4 expression models [88]

L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice

Studied compound reproduces some functions inherent for BDNF