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For example, in the particular case of those mood disorders that have been related to a high incidence of suicidal acts, there is major depression, in which a significant increase in cortisol levels has been established due to hyperactivity of the HPA axis, which correlates with cognitive impairment, decision making, and emotional processing in patients with major depression and suicide attempts[70,71]
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The pharmacokinetic rationale is questionable given tirzepatide 5-day half-life
