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Using this rationale, a synthetic lethality constraint was introduced into MetDP in order to account for those FDA-approved drugs that target genes involved in a 'non-trivial lethal' double combination (i.e

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The sedative benzodiazepines, as well as the CNS alpha-adrenergic agonist dexmedetomidine, have also proven useful for mitochondrial diseases, although their clearance may be slowed and effects prolonged (61