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In addition to this, there are various factors contributing to oxidative stress in FRDA, including mitochondrial labile iron, NRF2 expression, lipid peroxidation, and Ca 2+ homeostasis, which means therapeutics may need to combat a number of these factors to overcome oxidative stress
[DOI] [PubMed] [Google Scholar] 235.Lopez-Montero E., Rosa dos Santos J.-F., Torres-Labandeira J.J., Concheiro A., Alvarez-Lorenzo C
Smoking: This introduces massive amounts of oxidative stress
