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Certain patients naturally resist ICIs, while others show a significant reduction in treatment effectiveness or fail to respond after a set treatment period [117]

however, no change in medication or dose was allowed

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Allergic Cross-Reactivity of Cobalamins Since vitamin B12 can occur in various forms, the possibility of an allergic cross-reaction to different cobalamin variants seems likely, but based on the available literature data [80,81,82,83,84], this hypothesis cannot be unequivocally confirmed or ruled out