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However, it was not until 1919 that the first pathological evidence was obtained by Trtiakoff who provided a description of significant neuromelanin loss in SNc neurons and the presence of Lewy bodies (LBs) [33], cytoplasmatic structures previously reported by Frederic Lewy in PD-affected brains [34]

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Direct intake of vitamin B12 can often noticeably improve your energy levels

The link occurs through the -carboxyl group instead of the expected -carboxyl group of glutamate, making the molecule stable, which will not be degraded by aminopeptidases (Lu, 2013)