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For instance, a prolonged consumption of water with increased nitrate levels by dairy cattle is known to impair protein metabolism and glucose utilization
J Hazard Mater (2022) 439:129652
A study using a three-dimensional tumour sphere model combined with CRISPR-Cas9 screening reported that Nrf2 overactivation was essential for lung tumour proliferation and survival, whereas silencing of Nrf2 predisposed spherical cells to ferroptosis, which was also consistent with clinical observations [77]
Inflammation in chronic wounds
