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Dysbiosis in CKD has been touted to be due to slow intestinal transit time, delivery of undigested protein to the colon, decreased dietary fiber intake, iron therapy, frequent use of proton pump inhibitors and antibiotics [43]

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The core mechanism of action of epicatechin is the inhibition of myostatin, which belongs to the transforming growth factor- (TGF-) superfamily and acts as an endogenous negative regulator of skeletal muscle mass