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Peripheral effects Via the AMY2 and AMY3 receptors Cagrilintide acts peripherally: Slowing of gastric emptying , stronger than with GLP-1 Suppression of postprandial glucagon , helps control postprandial glycemic spikes Modulation of bone remodeling (via AMY3), a neutral effect, but clinically monitored Synergy with GLP-1 (the mechanistic basis of CagriSema) The main innovation is the complementarity with the GLP-1 pathway : GLP-1 suppresses appetite via the arcuate nucleus of the hypothalamus (POMC neurons, AgRP/NPY inhibition) Amylin suppresses appetite via the area postrema (CGRP-like neurons) Two independent centers, two independent mechanisms

Today, we'll explore the profound connection between iron overload and malignancy, and discover evidence-based strategies to protect your health

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Balance with fiber and healthy fats A high-protein diet should still include adequate fiber (from fruits, vegetables, whole grains, etc.) and healthy fats (e.g., nuts, seeds, olive oil) to support digestion, heart health and nutrient absorption