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Early-life innate immune hyperactivation has been observed in allergic children, while asthmatic children display immune dysregulation characterized by reduced IFN- production and ILC2 expansion in response to rhinovirus or LPS stimulation (145)

Methods Cell lines and reagents HEK293T and HeLa cells were maintained in high-glucose DMEM (Sigma-Aldrich, D6429) containing 10% fetal calf serum (Sigma-Aldrich, P4333), 100 U ml 1 penicillin and 100 g ml 1 streptomycin at 37 C and 5% CO 2

Effects of histidine and n-acetylcysteine on experimental lesions induced by doxorubicin in sciatic nerve of rats