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was supported by a grant from the National Research Foundation of Korea (2019R1A5A6099645)

During lens differentiation, crystallin levels are highly upregulated, while degradation of organelles such as nuclei, mitochondria, endoplasmic reticulum, and ribosomes occurs (148)

Research on colorectal cancer has revealed the dual regulatory role of the chromatin remodeling factor ATRX: The deletion of ATRX upregulates the function of p53 through the Daxx/MDM2 pathway (the expression of p21 is increased by 3.2 times), and at the same time inhibits the activation of the ATM/Chk2 pathway (the number of H2AX foci is reduced by 42%)

Wichman J, Winther KH, Bonnema SJ, Hegeds L