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The addition of induction chemotherapy to preoperative, concurrent chemoradiotherapy improves tumor response in patients with esophageal adenocarcinoma

[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Davis LE, Oyer R, Beckham JD, Tyler KL

Subtle improvements in sleep quality Reduced morning stiffness Slightly improved activity tolerance Possible temporary sensitivity at injury sites Gradual reduction in baseline discomfort Progressive Phase (Weeks 4 to 8) The middle phase of treatment typically brings more noticeable improvements

Increased activity of the mitochondrial enzyme aldehyde dehydrogenase 2 (ALDH2) has been shown to have a protective effect against cardiac ischemia in animal models, and the postulated mechanism given by the investigators was 4-hydroxynonenal metabolism