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For example, in the hyperaccumulator Cretan brake fern ( Pteris cretica L.) As causes decreased DNA methylation ( VIM1 (Variant In Methylation/Orthrus), which is a methylcytosine binding protein, led to higher As tolerance and lower levels of this metalloid in A

Analyses of other potential off-target protein interactions through multiple sequence alignments of the full Kringle domains from LPA, PLG, plasminogen activator urokinase (PLAU), plasminogen activator tissue type (PLAT) and prothrombin (F2) support the compound selectivity rationale (Extended Data Fig

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These investigations may provide valuable insights into its use as a monotherapy or adjunct therapy in diabetes care