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Oct 2013;149(10):1173-1179
Insufficient protein during weight loss accelerates muscle loss, which undermines body composition goals and metabolic rate
In addition to oligonucleotide therapeutics, some small-molecule NNMT inhibitors have been reported recently [5659] and several have shown effectiveness in the prevention or treatment of obesity and T2D in vitro [60, 61] or in preclinical animal models [10, 58, 62], validating NNMT as a pharmacological drug target
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