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Weeks 4-6 : Noticeable improvement in skin firmness, reduction in fine lines and wrinkles (particularly around eyes and mouth), enhanced skin tone evenness, and accelerated healing of any existing wounds or blemishes

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If the patient is critically ill, or has neurologic disease, an infectious disease or hyperthyroidism, considerably higher doses may be indicated

Viral triggers and reactivation As in other chronic diseases, ME/CFS involves an asymptomatic predisposition stage, then a prodromal stage, followed by symptomatic disease (59)