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A person can have high total B12 but poor intracellular use, especially when MMA is high, homocysteine is high, or there are neurologic symptoms such as numbness or gait trouble

We speculate that specificity of antigen presenting cells, such as macrophage, may need to be taken into consideration and probed further for development of an anti-tumor response

The FUT2 secretor variant p.Trp154Ter influences serum vitamin B 12 concentration via holo-haptocorrin, but not holo-transcobalamin, and is associated with haptocorrin glycosylation Hum Mol Genet 2017;26:4975-88

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