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CD38 mAb effects against MM can be maximized by combination therapies with immunomodulatory imide drugs (IMiDs), proteasome inhibitors (PIs), anti-programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) antibodies, or cellular therapies for the treatment of MM, especially in patients with relapsed or refractory MM (R/R MM) and drug-resistant MM

This approach emerged pragmatically from research schedules but aligns well with receptor recovery kinetics and avoids the potential tolerance development that continuous daily dosing over many weeks might produce