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For instance, drug exposure drives the phenotypic alterations of tumor cells, including dedifferentiation, EMT or trans-differentiation, marked by upregulated EMT-related transcriptional factors (TFs), including Zinc finger E-box binding homeobox 1 (ZEB1), ZEB2 and SLUG, that suppress pro-apoptotic proteins (BIM, BMF) and activate anti-apoptotic proteins (Bcl-xL, BCL- 2, MCL1) [38,39,40]

It visibly smooths fine lines and locks in hydration for 72 hours, revealing a glass-like radiance with no greasy residue

2 Affected individuals recalled a tick bite followed by a red, expanding rash several weeks before the arthritis onset