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Are tissue-specific vulnerabilities, similar to the example of erythroid-specific ALAS and its unique vulnerability to translational repression by activated apo-IRP, at play

The opposing roles of NO and oxidative stress in cardiovascular disease

Maubon J, Scanlan M, Thurmond S, Rouanet P

Much controversy has arisen around overexpression in nematodes and Drosophila, but few attempts have been made to further characterize the tissue-specific roles and define activities of sirtuins in these genetic systems by manipulationfor example, 20 years after the initial studies, no tissue-specific role for nematodes SIR-2.1 has been reported to date