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Yi CA, Shin KM, Lee KS, Kim BT, Kim H, Kwon OJ, et al

The most common is hyperpigmentation due to inflammation which in turns triggers the production of melanin as a means of protecting the skin

On the other hand, decreased activity of HMG CoA reductase, the enzyme that controls the rate of de novo cholesterol synthesis by the cell, leads sequentially to a fall in cell cholesterol, increased expression of apo B/E (LDL) receptors, enhanced uptake of cholesterol from the circulation, and a reduction in the plasma cholesterol concentration

Both LA and ALA serve as essential fatty acids and precursors for extended polyunsaturated fatty acids