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By protecting the skin from environmental stressors such as pollution and UV radiation, glutathione helps prevent premature aging and maintains the skin's youthful appearance

Antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and other antioxidant molecules are the defense used against ROS: ascorbic acid (vitamin C), tocopherol (vitamin E), vitamin A, flavonoid and ubiquinone

Studies of individual with both SNPs (C677T and A1298C) showed that subjects with heterozygosity for both mutations resulted in an even lower MTHFR activity than heterozygosity for single MTHFR mutations, while no subjects carry both homozygote for MTHFR mutations regardless which SNPs 15 Furthermore, There were studies of multiple polymorphisms of one-carbon metabolism and schizophrenia symptoms showed an increase negative symptoms severity with increase of risk alleles, suggesting a cumulative effects of risk SNPs in one-carbon metabolism 61

Both genetic ablation of PAAN/MIF and the nuclease-deficient mutant have been demonstrated to protect against dopaminergic neuron loss and mitigate behavioral impairments in the -syn preformed fibril mouse model of sporadic PD (Park et al., 2022)