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Moreover, persistent hyperglycaemia triggers activation of the (NF-B) pathway and release of pro-inflammatory factors, leading to an imbalance between the pro- and anti-inflammatory networks, resulting in an increase in reactive oxygen species and the production of a large number of inflammatory mediators, which affects the functioning of the mitochondria and leads to neuronal damage and degeneration (29)

Furthermore, change of lifestyle-related factors can aid in reducing or preventing the OIPN neurological side effects

Arctigenin suppresses transforming growth factor-1-induced expression of monocyte chemoattractant protein-1 and the subsequent epithelialmesenchymal transition through reactive oxygen species-dependent ERK/NF-B signaling pathway in renal tubular epithelial cells

10.1080/15563650.2019.1681442 11 LevineD.McDonaldR