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In addition, it disturbs the normal regulation of cell cycle by inducing cyclin-dependent kinase inhibitors (e.g., p27Kip1 and p21) (Heino et al., 1989), which will result in renal cellular hypertrophy

By incorporating the quadratic term, the aim is to achieve continuous and low doses of therapeutic drugs, as previous studies have shown improved outcomes with such an approach

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Lipids 170 SmithR
