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It works best as part of a comprehensive approach that includes dietary changes, physical activity, and consistent treatment

POMC is synthesized in corticotrophs of the anterior pituitary from the 267-amino-acid-long polypeptide precursor pre-pro-opiomelanocortin ( pre-POMC ), by the removal of a 26-amino-acid-long signal peptide sequence during translation

Based on natural mutations 90, 91 , site-directed mutagenesis, 92 and synthetic peptide studies 93 , the C-terminal helix (Fig