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At the same time, the methylation cycle is involved in the formation of glutathione, one of the bodys most important detoxifiers and radical scavengers (14 17)

Drugs 78:16251631 Kim Y-K (2022) RNA therapy: rich history, various applications and unlimited future prospects

In a biochemical assay using the FOX reagent, cellular ROS levels in the TA were determined to be approximately 20% lower than those in the EV and WT in the presence of H 2 O 2 (Figure 4B)

However, these detrimental effects were mitigated when the cells were treated with OH-Cbl