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doi: 10.1056/NEJMoa1712191, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 49.Emdin CA, Haas ME, Khera AV, Aragam K, Chaffin M, Klarin D, et al

Supplementation of B12 for a number of weeks prior to supplementing methylfolate, will avoid reactions to methylfolate