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Additionally, the multiplicity of hyperplasia in the 0.50 or 1.0 mg Benzo[a]pyrene treatment groups and the multiplicity of adenomas in the 1.0 mg group are significantly higher than in the vehicle group

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A cartilage matrix glycoprotein, a membrane-associated protein synthesized by chondrocytes, has been demonstrated to bind copper and exert some oxidase activity similar with ceruloplasmin, which may function as an important copper transporter in chondrocytes and a potential chondrogenic marker (Fife et al., 1986, 1993

However, the conversion of folic acid to active forms of folate is relatively slow in human cells (98), and exposure to high amounts of folic acid through supplements and fortified foods leads to the measurable appearance of unmetabolized folic acid in the blood