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2022 Aug;235(4):e13846

When gastric contents ascend into regions above the oesophagus, laryngopharyngeal reflux may occur (Reference Johnston, Dettmar and Strugala5) , potentially affecting the larynx, pharynx, paranasal sinuses and middle ear (Reference Lazarini and da Silva6)

Also called sickle cell anemia, SCD is a genetic disease that affects hemoglobin (1), with a specific mutation in the sixth codon of the -globin gene that leads to the substitution of glutamic acid by valine, resulting in the polymerization of red blood cells (2) and causing anemia due to chronic hemolysis of the red blood cells (RBCs)

The cons of Opzelura include that it is more expensive than generic Ruxolitinib creams and that it may cause adverse effects such as skin irritation and an elevated risk of infections, which are also possible with Ruxolitinib