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Skeletal muscle acidosis and dysregulated protons have also been found in patients during or after exercise (401404)

doi: 10.1080/11263504.2017.1301590 10

The VEGFR2-Akt-eNOS signaling pathway was directly activated (i.e., without the need for other known ligands or shear stress), controlling vasomotor tone (both smooth muscle and endothelium), and the Src-Caveolin-1-eNOS pathway was activated [103,104]

Rare cases of allergic contact dermatitis have been described with prolonged copper exposure, so persistent or worsening inflammation should prompt discontinuation and medical evaluation
