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Tumor cells treated with pH-sensitive liposomes survived only 35% of the time after 48 hours, but normal cells survived 100% of the time, according to in vitro tumor cytotoxicity assays

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52 As a calcineurin inhibitor, tacrolimus inhibits interleukin (IL)-2 and IL-4 gene transcription, downregulates the expression of other T-cell cytokines and prevents T-cell response to antigens