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In particular, GSTP1-1 is able to protect the tumor cells from apoptosis signals by inhibiting c-Jun N-terminal kinase (JNK)a member of the MAPK pathwaynon-catalytically, by direct proteinprotein association 25,26

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Interestingly, ghrelin requires acylation on its serine-3 residue by the enzyme GOAT in order for the peptide to bind to GHSR1a (Kojima et al., 1999

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