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Many cellular, model organism or human studies do not consider whether the impact on glucose metabolism of physiologic doses of melatonin (nighttime circulating melatonin concentrations are typically ~10100 pg/ml) differs from that of much higher, pharmacologic doses (peak levels after typical OTC oral dose of 15 mg are ~50010,000 pg/mL, depending on the dose, formulation, and interindividual variability), these considerations may reveal important biology of therapeutic relevance[80]

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Rare but serious side effects may include allergic reactions and infections