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In rheumatoid arthritis models, probiotic-induced DCA/LCA activated TGR5 (likely Gs-cAMP mediated given the anti-inflammatory outcome) to suppress Th1/Th17 responses, an effect nullified by the TGR5 antagonist SBI-115 (79)

Thus, light spectrum-dependent changes in its activity may influence glutathione content in these compartments

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