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c-Myc directly activates the genes involved in nucleotide synthesis, including thymidylate synthase for pyrimidine metabolism, inosine monophosphate dehydrogenase 1 and 2 for purine metabolism, and phosphoribosyl pyrophosphate (PRPP) synthetase 2 for the production of PRPP, which is a common precursor for purine and pyrimidine nucleotides

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Dai P, Mao Y, Sun X, Li X, Muhammad I, Gu W, Zhang X (2017) Attenuation of oxidative stress-induced osteoblast apoptosis by curcumin is associated with preservation of mitochondrial functions and increased Akt-GSK3 signaling

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It could be safe for some with prescription and care monitoring, but compounded items have unique risks, including lack of quality control and dosing issues

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Bjelakovic et al

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