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Collier, A
Dysfunction or weakness in these muscles can further exacerbate imbalanced muscle activation patterns, indirectly increasing the load on the ACL
If human trials reveal minimal systemic absorption after oral dosing, the peptide's utility for GERD would be limited to topical esophageal application or parenteral routes, both of which present practical barriers for chronic reflux management
Preclinical results with nangibotide were very promising and early trials suggested that it was safe in patients [284, 285, 287]
