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The review included questionnaires and case reports that described people developing manic episodes and other mood symptoms such as agitation, alertness, insomnia, and impulsivity after very high, short-term intake of energy drinks (for example, six to nine small cans per day over days to weeks)

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laevis oocytes expressing human neurotransmitter receptors, it was found that the KBs acetone and BHB had differential effects on the regulation of GABA, NMDA and glycine receptors at physiologically relevant concentrations for BHB (up to 5 mM