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BPC-157 has demonstrated systemic activity when administered orally (in some models), though subcutaneous delivery is most commonly used in the published literature
doi: 10.1007/s12602-024-10223-5 66 ShalabyA
78 While it may be tempting to conclude from these studies that NOX inhibition with celastrol or other drugs may represent an interesting therapeutic goal in COPD, it is important to recall that individuals with genetically defined NOX deficiencies are afflicted by life-threatening bacterial infections
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